RIFAMPICIN RESISTANCE IN TUBERCULOSIS PATIENTS: CAUSE-RELATED FACTORS IN INDONESIA 2017-2018

Authors

  • Dina Bisara Lolong
  • Kristina
  • Lamria Pangaribuan
  • Siti Isfandari
  • Noer Endah Pracoyo
  • Raflizar
  • Maria Holly Herawati

Keywords:

tuberculosis, rifampicin-resistance, Indonesia

Abstract

Drug-resistant tuberculosis (DR TB) is a disease that impacts public health with its increasing number of cases. Using data from the national cross-sectional Anti-Tuberculosis Drug Resistance Survey conducted in 2017-2018, this study aimed to identify factors contributing to Indonesia’s high proportion of rifampicin resistance. The independent variables predicted to affect rifampicin-resistant TB occurrence based on the available survey data were: age, gender education, employment status, area of residence, place of residence, have lived with TB patients, and treatment status. The data analysis was done using logistic regression. Among 3,431 smear-positive patients identified with TB, 3,234 were confirmed to be rapid molecular test positive, and 2,956 were Mycobacterium tuberculosis (MTB) sensitive. While the other 170 (5.25%) were identified with rifampicin-resistant tuberculosis (RR-TB). Patients with TB retreatment were 8.34 times more likely to have RR-TB, and females were also more likely to have RR-TB 1.38 times more than males (odds ratio (OR) = 1.38; 95% confidence interval (CI): (1.069-1.885), p=0.021). Living with TB patients for at least two years showed no significant difference. Other influential sociodemographic factors, including sex, TB case treatment status, and place of residence, were shown to have a difference in the risk of RR-TB. In conclusion, patients with TB retreatment are at high risk of RR-TB. Therefore, it is crucial to monitor the treatment of new tuberculosis patients to prevent treatment dropout and avoid RR-TB.

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Published

2023-05-29 — Updated on 2024-01-04

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