MAGNESIUM INTAKE AS A POTENTIAL THEURAPEUTIC APPROACH FOR OBESITY AND METABOLIC SYNDROME: A LITERATURE REVIEW

Abstract

Magnesium plays a crucial role in metabolic processes, influencing various aspects of health, including glucose regulation, insulin sensitivity, and lipid metabolism.  This literature review aims to summarize current evidence on the potential role of dietary magnesium intake as a therapeutic strategy for managing obesity and metabolic syndrome.  A selection of relevant articles published from 2019 to 2024 was reviewed based on defined inclusion and exclusion criteria.  The articles were sourced from PubMed, ScienceDirect, and Google Scholar databases.  This review was conducted following the PRISMA guidelines to ensure a systematic and transparent approach.  Out of 8,662 articles initially retrieved, 14 met the eligibility criteria and were proceeded to the review.  Of the selected articles, 4 employed RCTs including different dosage of magnesium supplement 250-300 mg/day, with duration 12-24 weeks were entered to this study.  Furthermore, 1 RCT recommends an RDA of magnesium intake for children and adolescents of 360-410 mg/day.  Five articles utilized cross-sectional designs while there were 3 cohort studies and 1 case-control study.  An inverse association has been consistently reported between magnesium intake, whether from diet or supplementation, and the risk of metabolic disorders.  This review highlights various studies that examine the effects of magnesium supplementation on health outcomes, alongside those focusing on the benefits of consuming magnesium-rich foods.  By exploring both dietary and supplemental magnesium intake, this review provides a balanced perspective on how magnesium affects health, considering different sources and forms of intake.