PREDICTORS OF CORONAVIRUS DISEASE 2019 (COVID-19) AMONG PEDIATRIC PATIENTS AT A NATIONAL INFECTIOUS DISEASES HOSPITAL, THAILAND

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Keywords:

Predictors, COVID-19, Pediatrics, patients under investigation, thailand

Abstract

Children are at risk of contracting SARS-CoV-2, but data on risk  factors for coronavirus disease 2019 (COVID-19) among children are limited  and inconsistent.  In order to determine predictors of COVID-19 among  pediatric patients under investigation (PUIs), a retrospective analysis was carried at Bamrasnaradura Infectious Diseases Institute, Nonthaburi Province,  Thailand between March 2020 and April 2021 of pediatric patients under  15 years of age who met the national case definition of PUIs for COVID-19  and required medical attention.  Nasopharyngeal and oropharyngeal swabs of pediatric PUIs (n = 165; 60% male, median (interquartile range)  age = 3 (1-8) years) were subjected to SARS-CoV-2 RT-qPCR assay.   Demographic, clinical, laboratory, and radiographic characteristics were compared between RT-qPCR positives (n = 18, 11%) and negatives  (n = 147, 89%).  Predictors of COVID-19 determined using a multiple logistic  regression analysis revealed presence of COVID-19 cases in household  (adjusted odds ratio (aOR) = 12.32, 95% confidence interval (CI): 3.87-39.26, p-value <0.001) and body temperature <37.5oC (aOR = 5.48, 95% CI: 1.03-29.27 p-value = 0.047) were independent risk factors for COVID-19 among pediatric PUIs.  As this was a cross-sectional study conducted at one site, a multi-center study involving a larger cohort of patients will be needed to validate the findings.

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Published

2021-09-30