RESEARCH NOTE PRESENCE OF HEPATITIS B VIRUS IN PARAFFIN-EMBEDDED LIVER TISSUES OF PATIENTS WITH HEPATOCELLULAR CARCINOMA
Pattaratida Sa-nguanmoo1, Salyavit Chittmittraprap2, Pisit Tangkijvanich2, Naruemon Wisedopas3, and Yong Poovorawan1
Keywords:
hepatitis B virus, hepatocellular carcinoma, liver cell differentiation stage, liver tissue, mutationAbstract
There are limited virological data regarding hepatitis B virus in liver tissues of hepatocellular carcinoma (HCC) patients. The study examined correlation between virological data and HCC status in 76 HCC patients classified into HBV infection status, genotype, mutation, and HBV DNA and covalently closed circular DNA (cccDNA) copies/cell. Genotype C was the most prevalent (70%); deletion of preS1 was present in 43% and novel C1673G/A and C1773T/A in 62% of region 3 mutations of HBV samples sequenced. Stage of liver cell differentiation stage, serological status of HCC patients and HBV genotype were strongly associated with preS deletion (p-value <0.001). Functional nature of these findings awaits further investigation.
Published
2020-07-11 — Updated on 2021-07-01
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- 2021-07-01 (2)
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RESEARCH NOTE PRESENCE OF HEPATITIS B VIRUS IN PARAFFIN-EMBEDDED LIVER TISSUES OF PATIENTS WITH HEPATOCELLULAR CARCINOMA: Pattaratida Sa-nguanmoo1, Salyavit Chittmittraprap2, Pisit Tangkijvanich2, Naruemon Wisedopas3, and Yong Poovorawan1. (2021). The Southeast Asian Journal of Tropical Medicine and Public Health, 51(3), 366. https://journal.seameotropmednetwork.org/index.php/jtropmed/article/view/175 (Original work published 2020)