REVIEW SERUM ENZYME ACTIVITY, TRACE ELEMENTS AND EXCITATORY AMINO ACIDS IN UNCOMPLICATED AND CEREBRAL MALARIA: A REVIEW
Saira Baloch and Xiaofang Pei
Keywords:amino acids, cerebral malaria, enzyme activity, trace metal, malaria
Malaria can be fatal in the form of cerebral malaria, which affects the brain of patients leading to coma and finally death. Cerebral malaria is caused by Plasmodium falciparum when infected red blood cells (RBC) obstruct blood circulation in the small blood vessels of the brain. Very little is known regarding metabolic abnormalities of patients with malaria including cerebral malaria, of the many factors affecting metabolism, trace metals, which are cofactors of many enzymes, can profoundly affect metabolic activities. The review explored the influence of trace metals and excitatory amino acids on activities of enzymes in malaria and cerebral malaria. This area of research has received little attention and a thorough understanding of the roles of these two factors on enzyme activities in human malaria should have a significant impact on disease control and maintaining patients’ optimal health.